In 1975, Dong Thap Primary Teachers Training College was founded in Dong Thap Muoi on the decision of the Ministry of Education and Youth.

Secondary Teachers Training College was established on the decision of the People's Committee of Dong Thap province on December 17th, 1977.

The College was then recognized as Dong Thap Teachers Training College on the 1984 decision by the President of the Ministers’ Council.

In 1989, under the instruction of Dong Thap Party Committee and People's Committee, the four professional education colleges of Dong Thap Teachers Training, Primary Teachers Training, Kindergarten Teachers Training and Managers Education were incorporated and became Dong Thap Teachers Training College, one of the first multi-level, multi-major and multi-training format colleges in the country.

On January 10th 2003, Dong Thap University was established by Decision No. 08/2003/QÐ-TTg by the Prime Minister based on the upgrading the Pedagogical College of Dong Thap.

On September 4, 2008, Pedagogical University of Dong Thap was renamed as Dong Thap University, which is a multi-level, multi-major and multi-training format University.